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1

Kanamycin and its derivative, arbekacin: significance and impact

Hotta, Kunimoto, Kondo, Shinichi

Journal:

The Journal of Antibiotics

Year:

2018

Language:

english

File:

PDF, 878 KB

english, 2018

2

ChemInform Abstract: Enzymatic 1-N-Acetylation of Paromomycin by an Actinomycete Strain with Multiple Aminoglycoside Resistance and Paromomycin Sensitivity.

Atsuko Sunada, Mutsuyasu Nakajima, Yoko Ikeda, Shinichi Kondo, Kunimoto Hotta

Journal:

Year:

2000

File:

PDF, 24 KB

2000

3

Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes

Kunimoto Hotta, Kunihiko Hayashi, Jun Ishikawa, Munekazu Tagawa, Katsuyuki Hashimoto, Satoshi Mizuno, Kazuo Suzuki

Journal:

Immunology Letters

Year:

1990

Language:

english

File:

PDF, 601 KB

english, 1990

4

Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications

S. Kondo, Kunimoto Hotta

Journal:

Journal of Infection and Chemotherapy

Year:

1999

Language:

english

File:

PDF, 175 KB

english, 1999

5

Construction of pRES18 and pRES19, Streptomyces-Escherichia coli shuttle vectors carrying multiple cloning sites

Jun Ishikawa, Yasuhiro Niino, Kunimoto Hotta

Journal:

FEMS Microbiology Letters

Year:

1996

Language:

english

File:

PDF, 305 KB

english, 1996

6

FramePlot: a new implementation of the Frame analysis for predicting protein-coding regions in bacterial DNA with a high G+C content

Jun Ishikawa, Kunimoto Hotta

Journal:

FEMS Microbiology Letters

Year:

1999

Language:

english

File:

PDF, 274 KB

english, 1999

7

Trends of Arbekacin-resistant MRSA Strains in Japanese Hospitals (1979 to 2000)

Tsuchizaki, Naofumi, Ishino, Keiko, Saito, Fumiko, Ishikawa, Jun, Nakajima, Mutsuyasu, Hotta, Kunimoto

Journal:

The Journal of Antibiotics

Year:

2006

Language:

english

File:

PDF, 152 KB

english, 2006

8

Bispolides, Novel 20-Membered Ring Macrodiolide Antibiotics from Microbispora

Okujo, Noriyuki, Iinuma, Hironobu, George, Annie, Eim, Khor Siew, Li, Tan Lee, Ting, Ng Szu, Jye, Tan Chin, Hotta, Kunimoto, Hatsu, Masahiro, Fukagawa, Yasuo

Journal:

The Journal of Antibiotics

Year:

2007

Language:

english

File:

PDF, 76 KB

english, 2007

9

Distribution and identification of actinomycetes lysing cyanobacteria in a eutrophic lake

Yoko Yamamoto, Takanori Kouchiwa, Yoshikuni Hodoki, Kunimoto Hotta, Hideaki Uchida, Ken-Ichi Harada

Journal:

Journal of Applied Phycology

Year:

1998

Language:

english

File:

PDF, 165 KB

english, 1998

10

Construction of pRES18 and pRES19, Streptomyces-Escherichia coli shuttle vectors carrying multiple cloning sites

Jun Ishikawa, Yasuhiro Niino, Kunimoto Hotta

Journal:

FEMS Microbiology Letters

Year:

1996

Language:

english

File:

PDF, 323 KB

english, 1996

11

Molecular cloning and expression of canine interleukin 8 cDNA

Yasunobu Matsumoto, Amro Mohamed, Takashi Onodera, Hirotomo Kato, Takashi Ohashi, Ryo Goitsuka, Hajime Tsujimoto, Atsuhiko Hasegawa, Shuichi Furusawa, Kazuhiro Yoshihara, Jun Ishikawa, Kunimoto Hotta,

Journal:

Year:

1994

Language:

english

File:

PDF, 757 KB

english, 1994

12

FramePlot: a new implementation of the Frame analysis for predicting protein-coding regions in bacterial DNA with a high G+C content

Jun Ishikawa, Kunimoto Hotta

Journal:

FEMS Microbiology Letters

Year:

1999

Language:

english

File:

PDF, 276 KB

english, 1999

13

Ribosomal resistance of an istamycin producer, Streptomyces tenjimariensis, to aminoglycoside antibiotics

Hirokazu Yamamoto, Kunimoto Hotta, Yoshiro Okami, Hamao Umezawa

Journal:

Biochemical and Biophysical Research Communications

Year:

1981

Language:

english

File:

PDF, 332 KB

english, 1981

14

Nucleotide sequence and transcriptional start point of the kan gene encoding an aminoglycoside 3-N-acetyltransferase from Streptomyces griseus SS-1198PR

Jun, Ishikawa, Kunimoto, Hotta

Journal:

Year:

1991

Language:

english

File:

PDF, 895 KB

english, 1991

15

Synthesis and inhibitory activity of 8-substituted 2-deoxy-β-KDO against CMP-KDO synthetase

Adachi, Hayamitsu, Kondo, Ken-ichiro, Kojima, Fukiko, Umezawa, Yoji, Ishino, Keiko, Hotta, Kunimoto, Nishimura, Yoshio

Journal:

Natural Product Research

Year:

2006

Language:

english

File:

PDF, 168 KB

english, 2006

16

Cloning of a canine gene homologous to the human interleukin-8-encoding gene

Jun, Ishikawa, Shoichi, Suzuki, Kunimoto, Hotta, Yoshikazu, Hirota, Satoshi, Mizuno, Kazuo, Suzuki

Journal:

Year:

1993

Language:

english

File:

PDF, 279 KB

english, 1993

17

Secondary aminoglycoside resistance in aminoglycoside-producing strains of Streptomyces

Hotta, Kunimoto, Ishikawa, Jun, Ogata, Tetsu, Mizuno, Satoshi

Journal:

Year:

1992

Language:

english

File:

PDF, 576 KB

english, 1992

18

Antisense RNA: Effect of ribosome binding sites, target location, size, and concentration on the translation of specific mRNA molecules

Daugherty, Bruce L., Hotta, Kunimoto, Kumar, Chandrika, Yong Ho Ahn,, Zhu, Jingdong, Pestka, Sidney

Journal:

Genetic Analysis Techniques

Year:

1989

Language:

english

File:

PDF, 1.52 MB

english, 1989

19

[Part 1: Biological Sciences] || Anti-mRNA: Specific Inhibition of Translation of Single mRNA Molecules

Sidney Pestka, Bruce L. Daugherty, Vincent Jung, Kunimoto Hotta and Robert K. Pestka

Journal:

Proceedings of the National Academy of Sciences

Year:

1984

Language:

english

File:

PDF, 647 KB

english, 1984

20

Decontamination of Aflatoxin-Forming Fungus and Elimination of Aflatoxin Mutagenicity with Electrolyzed NaCl Anode Solution

Suzuki, Tetsuya, Noro, Takashi, Kawamura, Yukio, Fukunaga, Kenji, Watanabe, Masumi, Ohta, Mari, Sugiue, Hisashi, Sato, Yuri, Kohno, Masahiro, Hotta, Kunimoto

Journal:

Journal of Agricultural and Food Chemistry

Year:

2002

Language:

english

File:

PDF, 199 KB

english, 2002

21

Detection of Human Leukocyte Interferon-αA and -α 2 Genes in Genomic DNAs by the Use of Deoxyoctadecyloligonucleotide Probes

HOTTA, KUNIMOTO, MONAHAN, JOHN, COLLIER, KENNETH J., PESTKA, SIDNEY

Journal:

Journal of Interferon Research

Year:

1988

Language:

english

File:

PDF, 5.20 MB

english, 1988

22

Isolation and Bacterial Expression of a Murine Alpha Leukocyte Interferon Gene

DAUGHERTY, BRUCE, MARTIN-ZANCA, DIONISIO, KELDER, BRUCE, COLLIER, KENNETH, SEAMANS, T. CRAIG, HOTTA, KUNIMOTO, PESTKA, SIDNEY

Journal:

Journal of Interferon Research

Year:

1984

Language:

english

File:

PDF, 2.34 MB

english, 1984

23

Epoch-making milestones in antibiotic exploratory researches in Japan †

Hotta, Kunimoto

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2017

Language:

english

File:

PDF, 364 KB

english, 2017

24

Spectroscopic Characterization and the pH Dependence of Bactericidal Activity of the Aqueous Chlorine Solution.

NAKAGAWARA, Shunji, GOTO, Takeshi, NARA, Masayuki, OZAWA, Youichi, HOTTA, Kunimoto, ARATA, Yoji

Journal:

Analytical Sciences

Year:

1998

Language:

english

File:

PDF, 82 KB

english, 1998

25

Studies on the mode of action of amiclenomycin.

HOTTA, KUNIMOTO, KITAHARA, TAKEJI, OKAMI, YOSHIRO

Journal:

The Journal of Antibiotics

Year:

1975

Language:

english

File:

PDF, 3.08 MB

english, 1975

26

Elimination of the ability of a kanamycin-producing strain to biosynthesize deoxystreptamine moiety by acriflavine.

HOTTA, KUNIMOTO, OKAMI, YOSHIRO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1977

Language:

english

File:

PDF, 2.00 MB

english, 1977

27

Biological studies on amiclenomycin.

KITAHARA, TAKEJI, HOTTA, KUNIMOTO, YOSHIDA, MAKOTO, OKAMI, YOSHIRO

Journal:

The Journal of Antibiotics

Year:

1975

Language:

english

File:

PDF, 3.37 MB

english, 1975

28

Resistance mechanisms of kanamycin-, neomycin-, and streptomycin-producing streptomycetes to aminoglycoside antibiotics.

HOTTA, KUNIMOTO, YAMAMOTO, HIROKAZU, OKAMI, YOSHIRO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1981

Language:

english

File:

PDF, 4.12 MB

english, 1981

29

Transfer of the leupeptin-producing ability of the strain, Streptomyces roseus MA839-A1, by conjugation.

UMEZAWA, HAMAO, OKAMI, YOSHIRO, HOTTA, KUNIMOTO

Journal:

The Journal of Antibiotics

Year:

1978

Language:

english

File:

PDF, 1.47 MB

english, 1978

30

Relationship between antibiotic resistance and antibiotic productivity in actinomycetes which produce aminoglycoside antibiotics.

HOTTA, KUNIMOTO, TAKAHASHI, ATSUSHI, OKAMI, YOSHIRO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1983

Language:

english

File:

PDF, 1.61 MB

english, 1983

31

2"-N-formimidoylistamycin A and B produced by Streptomyces tenjimariensis.

KONDO, SHINICHI, HORIUCHI, YUKIO, IKEDA, DAISHIRO, GOMI, SHUICHI, HOTTA, KUNIMOTO, OKAMI, YOSHIRO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1982

Language:

english

File:

PDF, 1.38 MB

english, 1982

32

Studies on new aminoglycoside antibiotics, istamycins, from an actinomycete isolated from a marine environmentt. III. Nutritional effects on istamycin production and additional chemical and biological properties of istamycins.

HOTTA, KUNIMOTO, YOSHIDA, MAKOTO, HAMADA, MASA, OKAMI, YOSHIRO

Journal:

The Journal of Antibiotics

Year:

1980

Language:

english

File:

PDF, 2.68 MB

english, 1980

33

Mechanism of resistance to aminoglycoside antibiotics in nebramycin-producing Streptomyces tenebrarius.

YAMAMOTO, HIROKAZU, HOTTA, KUNIMOTO, OKAMI, YOSHIRO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1982

Language:

english

File:

PDF, 2.91 MB

english, 1982

34

New antibiotic-producing streptomycetes, selected by antibiotic resistance as a marker. II. Features of a new antibiotic-producing clone obtained after fusion treatment.

HOTTA, KUNIMOTO, YAMASHITA, FUMIO, OKAMI, YOSHIRO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1985

Language:

english

File:

PDF, 6.30 MB

english, 1985

35

Multiple resistance to aminoglycoside antibiotics in actinomycetes.

HOTTA, KUNIMOTO, TAKAHASHI, ATSUSHI, SAITO, NORIKO, OKAMI, YOSHIRO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1983

Language:

english

File:

PDF, 3.04 MB

english, 1983

36

Mechanism of increased kanamycin-resistance generated by protoplast regeneration of Streptomyces griseus. I. Cloning of a gene segment directing a high level of an aminoglycoside 3-N-acetyltransferase activity.

HOTTA, KUNIMOTO, ISHIKAWA, JUN, ICHIHARA, MASARU, NAGANAWA, HIROSHI, MIZUNO, SATOSHI

Journal:

The Journal of Antibiotics

Year:

1988

Language:

english

File:

PDF, 729 KB

english, 1988

37

Mechanism of increased kanamycin-resistance generated by protoplast regeneration of Streptomyces griseus. II. Mutational gene alteration and gene amplification.

ISHIKAWA, JUN, KOYAMA, YASUMASA, MIZUNO, SATOSHI, HOTTA, KUNIMOTO

Journal:

The Journal of Antibiotics

Year:

1988

Language:

english

File:

PDF, 755 KB

english, 1988

38

Strain- and species-specific distribution of the streptomycin gene cluster and kan-related sequences in Streptomyces griseus.

HOTTA, KUNIMOTO, ISHIKAWA, JUN

Journal:

The Journal of Antibiotics

Year:

1988

Language:

english

File:

PDF, 714 KB

english, 1988

39

1-Epidactimicin, a new aminoglycoside antibiotic converted from fortimicin B by a blocked mutant of istamycin-producing Streptomyces tenjimariensis.

MORIOKA, MOTO, HOTTA, KUNIMOTO, IKEDA, DAISHIRO, NAGANAWA, HIROSHI, HAMADA, MASA, OKAMI, YOSHIRO

Journal:

The Journal of Antibiotics

Year:

1989

Language:

english

File:

PDF, 208 KB

english, 1989

40

Cloning of macromomycin apoprotein gene from Streptomyces macromomyceticus by use of 50-mer deoxynucleotide probes.

HORI, MAKOTO, SAKATA, NOBUO, NIINO, YASUHIRO, MAKABE, OSAMU, HAMADA, MASA, MIZUNO, SATOSHI, HOTTA, KUNIMOTO

Journal:

The Journal of Antibiotics

Year:

1988

Language:

english

File:

PDF, 864 KB

english, 1988

41

Biosynthetic similarity between Streptomyces tenjimariensis and Micromonospora olivasterospora which produce fortimicin-group antibiotics.

HOTTA, KUNIMOTO, MORIOKA, MOTO, OKAMI, YOSHIRO

Journal:

The Journal of Antibiotics

Year:

1989

Language:

english

File:

PDF, 435 KB

english, 1989

42

Pyrrolomycin group antibiotics inhibit substance P-induced release of myeloperoxidase from human polymorphonuclear leukocytes.

MASUDA, KAORI, SUZUKI, KAZUO, ISHIDA-OKAWARA, AKIKO, MIZUNO, SATOSHI, HOTTA, KUNIMOTO, MIYADOH, SHINJI, HARA, OSAMU, KOYAMA, MASAO

Journal:

The Journal of Antibiotics

Year:

1991

Language:

english

File:

PDF, 512 KB

english, 1991

43

PCR Inhibition Assay for DNA-targeted Antibiotics.

HOTTA, KUNIMOTO, ZHU, CHUN-BAO, PHOMSUWANSIRI, POOLSAK, ISHIKAWA, JUN, MIZUNO, SATOSHI, HATSU, MASAHIRO, IMAI, SATOSHI

Journal:

The Journal of Antibiotics

Year:

1995

Language:

english

File:

PDF, 532 KB

english, 1995

44

The Novel Enzymatic 3"-N-Acetylation of Arbekacin by an Aminoglycoside 3-N-Acetyltransferase of Streptomyces Origin and the Resulting Activity.

HOTTA, KUNIMOTO, SUNADA, ATSUKO, ISHIKAWA, JUN, MIZUNO, SATOSHI, IKEDA, YOKO, KONDO, SHINICHI

Journal:

The Journal of Antibiotics

Year:

1998

Language:

english

File:

PDF, 972 KB

english, 1998

45

Enzymatic 2'-N-Acetylation of Arbekacin and Antibiotic Activity of Its Product.

HOTTA, KUNIMOTO, ZHU, CHUN-BAO, OGATA, TETSU, SUNADA, AISUKO, ISHIKAWA, JUN, MIZUNO, SATOSHI, IKEDA, YOKO, KONDO, SHINICHI

Journal:

The Journal of Antibiotics

Year:

1996

Language:

english

File:

PDF, 557 KB

english, 1996

46

Acetylation of Aminoglycoside Antibiotics with 6'-Methylamino Group, Istamycin B and Micronomicin, by a Novel Aminoglycoside 6'-Acetyltransferase of Actinomycete Origin.

SUNADA, ATSUKO, IKEDA, YOKO, KONDO, SHINICHI, HOTTA, KUNIMOTO

Journal:

The Journal of Antibiotics

Year:

2000

Language:

english

File:

PDF, 256 KB

english, 2000

47

Role of Aminoglycoside 6'-Acetyltransferase in a Novel Multiple Aminoglycoside Resistance of an Actinomycete Strain #8. Inactivation of Aminoglycosides with 6'-Amino Group Except Arbekacin and Neomycin.

ZHU, CHUN-BAO, SUNADA, ATSUKO, ISHIKAWA, JUN, IKEDA, YOKO, KONDO, SHINICHI, HOTTA, KUNIMOTO

Journal:

The Journal of Antibiotics

Year:

1999

Language:

english

File:

PDF, 612 KB

english, 1999

48

Production of Selenohomocystine as an Antibiotic by a Marine Bacillus sp. No. 14 with Selenomethionine Resistance.

IMADA, CHIAKI, OKAMI, YOSHIRO, HOTTA, KUNIMOTO

Journal:

The Journal of Antibiotics

Year:

2002

Language:

english

File:

PDF, 510 KB

english, 2002

49

Characterization of a Bifunctional Aminoglycoside-Modifying Enzyme with Novel Substrate Specificity and Its Gene from a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus with High Arbekacin Resistance

ISHINO, KEIKO, ISHIKAWA, JUN, IKEDA, YOKO, HOTTA, KUNIMOTO

Journal:

The Journal of Antibiotics

Year:

2004

Language:

english

File:

PDF, 1.34 MB

english, 2004

50

New antibiotic-producing Streptomycetes, selected by antibiotic resistance as a marker. I. New antibiotic production generated by protoplast fusion treatment between Streptomyces griseus and S. tenjimariensis.

YAMASHITA, FUMIO, HOTTA, KUNIMOTO, KURASAWA, SHOGO, OKAMI, YOSHIRO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1985

Language:

english

File:

PDF, 6.29 MB

english, 1985

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